University of Manchester

X-ray imaging of co-electrosprayed hollow microspheres

Fenglei Zhou
Project Completed

Scientific Case

We successfully produced hollow spheres by co-electrospraying to act as a phantom (test object) for the validation of diffusion magnetic resonance imaging (MRI). However, currently, our ability to characterize the ground-truth geometry of these bulk
hollow spheres is limited. We have to date been assessing the micron-scale geometry of our materials mainly using scanning electron microscopy (SEM) and histological techniques, which sometimes provides inaccurate characterisation of the ground-truth geometry due to preparation problems caused by frozen fracture and only two-dimensional structural information. In order to obtain the desired three-dimensional images, we would like to carry out X-ray tomography using the micro- and nano-CT systems in the MXIF, with subsequent tomographic image reconstruction.
Polymers

Experiment Design

We are interested in both size and packing density of microspheres having around 10 microns in diameter. After discussion with Dr. Rob Bradley, two imaging systems including Versa XRM and Ultra NanoCT were recommended for packing density and size measurement, respectively.
Scanners and Rigs
Xradia MicroXCT
2
Not Required
2
We are interested in scanning microspheres in a liquid-filled MR tube with diameter of 5mm if possible.
2
Not Required
2
We are interested in scanning microspheres in a liquid-filled MR tube with diameter of 5mm if possible.

Sample & Safety

Polycaprolactone (PCL) hollow microspheres with diameter around 10 microns. PCL is biodegradable polyester and there is no reported harzard with ths polymer.
1
Low Hazard

Scan Records

Project Report